2-(heterocyclylthio) carbapenem derivatives, their preparation a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

540350, C07D48704, A61K 31395

Patent

active

052429148

ABSTRACT:
Compounds of formula (I): ##STR1## in which R.sup.a is a group of formula (II): ##STR2## where one of R' is a bond to the remainder of the compound, one more of R' is R.sup.2 and the others of R' are all hydrogen, R.sup.1 is hydrogen or methyl, R.sup.2 is hydrogen, optionally substituted alkyl, halogen, hydroxy, alkoxy, amino, alkanoylamino, alkanoyloxy, alkanoyl, carboxy, alkoxycarbonyl, cyano, --S(O).sub.j R.sup.9 where j is 0, 1 or 2 and R.sup.9 is alkyl, or --CONR.sup.6 R.sup.7 which is optionally substituted carbamoyl or heterocyclyl-carbonyl, --NR.sup.3 R.sup.4 is optionally substituted amino or heterocyclic, and --COOR.sup.5 is carboxy, --COO.sup.-, --COOM.sub.x, where M is a cation and x is the reciprocal of the valence of the cation M or protected carboxy and, where --COOR.sup.5 is carboxy, --COOM.sub.x or protected carboxy, the compound of formula (I) also contains an anion; l, m and n are independently 0, 1, 2 or 3, provided that (m+n) is an integer from 2 to 6; p is 0, 1 or 2; Y is a single bond, oxygen, sulfur or ##STR3## wherein R.sup.8 is hydrogen, alkyl or alkanoyl, and pharmaceutically acceptable salts and esters thereof. Such compounds are useful as antibiotics.

REFERENCES:
patent: 4460799 (1984-07-01), Perrin et al.
patent: 4552873 (1985-11-01), Miyadera et al.
patent: 4613595 (1986-09-01), Miyadera et al.
patent: 4640799 (1987-02-01), Kim et al.
patent: 4665170 (1987-05-01), Kim et al.
Hackh's Chemical Dictionary, 4th edition. McGraw Hill, 1969, p. 134.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

2-(heterocyclylthio) carbapenem derivatives, their preparation a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-(heterocyclylthio) carbapenem derivatives, their preparation a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-(heterocyclylthio) carbapenem derivatives, their preparation a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-487938

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.