2-(heterocyclylthio) carbapenem derivatives, their preparation a

Details 2-(heterocyclylthio) carbapenem derivatives, their preparation a 2-(heterocyclylthio) carbapenem derivatives, their preparation a

1992-02-04

1993-09-07

Mars, Howard T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D48704, A61K 31395

Patent

active

052429148

ABSTRACT:
Compounds of formula (I): ##STR1## in which R.sup.a is a group of formula (II): ##STR2## where one of R' is a bond to the remainder of the compound, one more of R' is R.sup.2 and the others of R' are all hydrogen, R.sup.1 is hydrogen or methyl, R.sup.2 is hydrogen, optionally substituted alkyl, halogen, hydroxy, alkoxy, amino, alkanoylamino, alkanoyloxy, alkanoyl, carboxy, alkoxycarbonyl, cyano, --S(O).sub.j R.sup.9 where j is 0, 1 or 2 and R.sup.9 is alkyl, or --CONR.sup.6 R.sup.7 which is optionally substituted carbamoyl or heterocyclyl-carbonyl, --NR.sup.3 R.sup.4 is optionally substituted amino or heterocyclic, and --COOR.sup.5 is carboxy, --COO.sup.-, --COOM.sub.x, where M is a cation and x is the reciprocal of the valence of the cation M or protected carboxy and, where --COOR.sup.5 is carboxy, --COOM.sub.x or protected carboxy, the compound of formula (I) also contains an anion; l, m and n are independently 0, 1, 2 or 3, provided that (m+n) is an integer from 2 to 6; p is 0, 1 or 2; Y is a single bond, oxygen, sulfur or ##STR3## wherein R.sup.8 is hydrogen, alkyl or alkanoyl, and pharmaceutically acceptable salts and esters thereof. Such compounds are useful as antibiotics.

REFERENCES:
patent: 4460799 (1984-07-01), Perrin et al.
patent: 4552873 (1985-11-01), Miyadera et al.
patent: 4613595 (1986-09-01), Miyadera et al.
patent: 4640799 (1987-02-01), Kim et al.
patent: 4665170 (1987-05-01), Kim et al.
Hackh's Chemical Dictionary, 4th edition. McGraw Hill, 1969, p. 134.

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