2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammat

Details 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammat 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammat

1992-08-03

1993-08-31

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544298, A61K 31505, C07D40304, C07D41304, C07D41704

Patent

active

052409295

ABSTRACT:
The present invention is novel compounds which are 2-heterocyclic-4,6-ditertiarybutyl-5-hydroxy-1,3-pyrimidines, where heterocyclic is selected from imidazole, thiazole, and oxazole, and pharmaceutically acceptable additional salts, bases, and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of, for example, preferably inflammation.

REFERENCES:
patent: 4636516 (1987-01-01), Kubo et al.

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