Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-06-24
1992-11-10
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548196, 546187, 546209, 544367, 544357, 514316, 514326, 514252, A61K 31495, C07D27704, C07D40100, C07D41300
Patent
active
051623609
ABSTRACT:
The present invention provides N-substituted aryl-N'-heterocyclic substituted ureas and thioureas of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino, substituted amino, or a monocyclic heterocyclic, or a carboxy group; and Het is a substituted monocyclic heterocyclic group containing two hetero atoms selected from nitrogen, oxygen or sulfur; which are useful in treating hypercholesterolemia and atherosclerosis.
REFERENCES:
patent: 3551442 (1970-12-01), Guillot et al.
patent: 3821239 (1974-06-01), Guillot et al.
patent: 4405644 (1983-09-01), Kabbe et al.
J. Med. Chem., 1979, vol. 22, No. 1, R. K. Y. Zee-Cheng et al., "Antileukemic Activity of Substituted Ureidothiazoles, Ureidothiadiazoles, and Related Compounds".
Creswell Mark W.
White Andrew D.
Daignault Ronald A.
Lee Mary C.
Newtson Ruth H.
Warner-Lambert & Company
Whittenbaugh Robert C.
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