2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uri

Details 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uri 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uri

1998-06-03

1999-11-02

Knode, Marian C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 278, 536 2781, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, 544242, 544276, 514 45, 514 49, 514 50, 514262, 514274, C07H 19073, C07H 19173

Patent

active

059773251

ABSTRACT:
This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.

REFERENCES:
patent: 3472837 (1969-10-01), Verheyden et al.
patent: 5378693 (1995-01-01), McCarthy et al.
patent: 5616702 (1997-04-01), Edwards et al.
De Clercq, "S-Adenosylhomocysteine Hydrolase Inhibitors as Broad Spectrum Antiviral Agents," Biochemical Pharmacology, 36(16), 2567-2575,(1987).
Ferrier, "4',5'-Unsaturated, Cyclic Compounds," Adv. Carbohydrate Chem. , 24, 250-251 (1969).
Fukukawa et al., "Synthesis of 2'(R)-Substituted Neplanocin A's (Nucleosides and Nucleotides XXXVII)," Chem. Pharm. Bull., 29, 597-600 (1981).
Katritzky et al., Comprehesive Heterocyclic Chemistry, vol. 5, Pergamon Press, New York, 1984, see p. 603.
Takenuki et al., "Design, Synthesis, and Antineoplastic Activity of 2'-Deoxy-2'-methylidenecytidine," J. Med. Chem., 31(6), 1063-1064 (1988).
Matsuda et al., "Alkyl Addition Reaction of Pyrimidine 2'-Ketonucleosides: Synthesis of 2'-Branched-Chain Sugar Pyrimidine Nucleosides (Nucleosides and Nucleotides LXXXI)," Chem. Pharm. Bull., 36(3), 945-953 (1988).
Hansske et al., "Nucleic Acid Related Compounds. 43. A Convenient Procedure for the Synthesis of 2' and 3'-Ketonucleosides," Tett. Lett., 34(15), 1589-1592 (1983).
Hansske et al., "2' and 3'-Ketonucleosides and Their Arabino and Xylo Reduction Products," Tetrahedron, 40(1), 125-135 (1984).
Taber's Cyclopedic Medical Dictionary, 17th Ed., C. L. Thomas (ed.), F. A. Davis Co., Philadelphia, PA, 1993, p. 340 only.
Ashwell et al., "The Synthesis of Some Branched-Chain-Sugar Nucleoside Analogues," Nucleic Acids Res., 15(5), 2157-2166 (Mar. 11, 1987).
Usui et al., "Synthesis of 2'-Deoxy-8,2'-ethanoadenosine and 3'-Deoxy-8,3'-ethanoadenosine (Nucleosides and Nucleotides. LXIV)," Chemical Pharmaceutical Bull., 34(1), 15-23 (Jan. 1986).

Affiliated with

Also associated with

Rating

2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uri does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uri, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uri will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2137026