2'-halomethylidene, 2'-ethenylidene and 2'-ethynl cytidine, urid

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 2781, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, 536 2855, 536 278, 544264, C07D47330, C07D47340, C07D23947, C07D23952

Patent

active

057928410

ABSTRACT:
This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.

REFERENCES:
patent: 3472837 (1969-10-01), Verheyden et al.
patent: 5378693 (1995-01-01), McCarthy et al.
patent: 5616702 (1997-04-01), Edwards et al.
De Clercq, "S-Adenosylhomocysteine Hydrolase Inhibitors as Broad Spectrum Antiviral Agents," Biochemical Pharmacology, 36(16), 2567-2575 (1987).
Ferrier, "4', 5'-Unsaturated, Cyclic Compounds," Adv. Carbohydrated Chem., 24, 250-251 (1969).
Fukukawa et al., "Synthesis of 2'(R)-Substituted Neplanocin A's (Nucleosides and Nucleotides XXXVII)," Chem. Pharm. Bull., 29, 597-600 (1981).
Katritzky et al., Comprehensive Heterocyclic Chemistry, vol. 5, Pergamon Press, New York, 1984, see p. 603.
Takenuki et al., "Design, Synthesis, and Antineoplastic Activity of 2'-Deoxy-2'-methylidenecytidine," J. Med. Chem., 31(6), 1063-1064 (1988).
Matsuda et al., "Alkyl Addition Reaction of Pyrimidine 2'-Ketonucleosides: Synthesis of 2'-Branched-Chain Sugar Pyrimidine Nucleosides (Nucleosides and Nucleotides LXXXI)," Chem. Pharm. Bull., 36(3), 945-953 (1988).
Hansske et al., "Nucleic Acid Related Compounds. 43. A Convenient Procedure for the Synthesis of 2' and 3'-Ketonucleosides," Tett. Lett., 34(15), 1589-1592 (1983).
Hansske et al., "2' and 3'-Ketonucleosides and Their Arabino and Xylo Reduction Products," Tetrahedron, 40(1), 125-135 (1984).
Taber's Cyclopedic Medical Dictionary, 17th Ed., C. L. Thomas (ed.), F. A. Davis Co., Philadelphia, PA, 1993, p. 340 only.
Ashwell et al., "The Synthesis of Some Branched-Chain-Sugar Nucleoside Analogues," Nucleic Acids Res., 15(5), 2157-2166 (Mar. 11, 1987).
Usui et al., "Synthesis of 2'-Deoxy-8,2'-ethanoadenosine and 3'-Deoxy-8,3'ethanoadenosine (Nucleosides and Nucleotides. LXIV)," Chemical Pharmaceutical Bull., 34(1), 15-23 (Jan. 1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

2'-halomethylidene, 2'-ethenylidene and 2'-ethynl cytidine, urid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2'-halomethylidene, 2'-ethenylidene and 2'-ethynl cytidine, urid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2'-halomethylidene, 2'-ethenylidene and 2'-ethynl cytidine, urid will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-389849

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.