2-Halomethyl derivatives of 2-amino acids

Details 2-Halomethyl derivatives of 2-amino acids 2-Halomethyl derivatives of 2-amino acids

1988-01-27

1989-09-12

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 9900

Patent

active

048662062

ABSTRACT:
2-(Fluoromethyl or chloromethyl)-2,5-diaminopentanoic acid, 2-(fluoromethyl or chloromethyl)-2,6-diaminohexanoic acid, and 2-fluoromethyl-2-amino-5-guanidinopentanoic acid, and certain derivatives thereof, are inhibitors of ornithine decarboxylase. Methods of preparing the compounds and derivatives are also described.

REFERENCES:
patent: 4288601 (1981-09-01), Kollonitsch
patent: 4325961 (1982-04-01), Kollonitsch
patent: 4418077 (1983-11-01), Bey
patent: 4423073 (1983-12-01), Gerhart
patent: 4439619 (1984-03-01), Bey
patent: 4446151 (1984-05-01), Gerhart

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