2-halogeno-oxetanocin A and phosphoric ester thereof

Details 2-halogeno-oxetanocin A and phosphoric ester thereof 2-halogeno-oxetanocin A and phosphoric ester thereof

1991-12-09

1994-02-01

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544244, 544277, C07D47340, A61K 3152, C07F 909, C07F 718

Patent

active

052833313

ABSTRACT:
It was found that 2-halogeno-oxetanocin A and 4'-phosphate thereof represented by the following general formula (1): ##STR1## wherein X represents a halogen atom and R represents a hydrogen atom or a phosphoric acid residue ##STR2## or salts thereof exhibit a strong antiviral activity and are useful as an active ingredient of therapeutic drug for viral diseases. Further, it was also found that the compounds of this invention are characterized in that they are not inactivated by adenosine deaminase widely present in living bodies and exhibit a high residual activity.

REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
patent: 4743689 (1988-05-01), Shimada, III
patent: 4918075 (1990-04-01), Zahler
patent: 5041447 (1991-08-01), Saito
patent: 5059690 (1991-10-01), Zahler
Yarchoan, Science, 245, p. 412 (1989).
Shimada I The Journal of Antibiotics vol. XXXIX, 1623-1625 (1986).
Shimada II The Journal of Antibiotics vol. XL, 1788-1790 (1987).

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