2-Halo-4-aminomethyl-6-alkyl-3-pyridinols useful as diuretics in

Details 2-Halo-4-aminomethyl-6-alkyl-3-pyridinols useful as diuretics in 2-Halo-4-aminomethyl-6-alkyl-3-pyridinols useful as diuretics in

1977-05-26

1978-10-31

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602949, 260296R, 260307R, A61K 31345, C07D21365

Patent

active

041235371

ABSTRACT:
Certain substituted 4-aminomethyl-3-pyridinols and their pharmaceutically acceptacle acid addition salts wherein the pyridinol nucleus may be further substituted with 1 to 2 nuclear substituents are useful as antihypertensive, diuretic and saluretic agents. These products may be prepared by halogenating an appropriately substituted pyridine salt.

REFERENCES:
patent: 4029816 (1977-06-01), Cragoe et al.
Klingsberg, Pyridine and Derivatives, vol. 3, frontispage, pp. 659 and 772-775, Interscience Publishers (1962).
Burger, Medicinal Chemistry, 2nd Ed., frontispage and pp. 79-81, Interscience Publishers, Inc. NY (1960).
Burlakova et al., Chem. Abstracts, vol. 61, cols. 6020-6021 (1964).
Zhizhina, Chem. Abstracts, vol. 66, abst. 92175z (1967).
Odintsova, Chem. Abstracts, vol. 68, abst. 1091w (1968).

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