2-halo-2'-fluoro ARA adenosines as antinoplastic agents

Details 2-halo-2'-fluoro ARA adenosines as antinoplastic agents 2-halo-2'-fluoro ARA adenosines as antinoplastic agents

1994-09-21

1997-08-26

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 274, 536 2763, A61K 3170

Patent

active

056611366

ABSTRACT:
The present invention is directed to certain 2'-fluoro, 2-substituted purine nucleosides which are toxic to cancerous cell lines.

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Huang et al., "Phosphorolytic Cleavage of 2-Fluoroadenine from 9-.beta.-D-Arabinofuranosyl-2-fluoroadenine by Escherichia coli. A Pathway for 2-Fluoro-ATP Production," Biochemical Pharmacology, 36(18), 2945-2950 (1987).
Struck et al., "Identification of Metabolites of 9-.beta.-D-Arabinofuranosyl-2-fluoroadenine, an Antitumor and Antiviral Agent," Biochemical Pharmacology, 31(11), 1975-1978 (1982).
Haertle et al., "Metabolism and Anti-human Immunodeficiency Virus-1 Activity of 2-Halo-2', 3'-dideoxyadenosine Derivatives," J. Biol. Chem., 263(12), 5870-5875 (1988).

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