2-H and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxaze

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

540547, A61K 3155

Patent

active

052815900

ABSTRACT:
The present invention provides a method for treating osteoporosis in a mammal comprising administering to said mammal a therapeutically-effective amount of a compound of Formula I: ##STR1##

REFERENCES:
patent: 3534019 (1970-10-01), Coyne
patent: 3624104 (1971-11-01), Cusic
patent: 3917649 (1975-11-01), Mueller
patent: 3989719 (1976-11-01), Mueller
patent: 3992375 (1976-11-01), Mueller
patent: 4045442 (1977-08-01), Mueller
patent: 4125532 (1978-11-01), Mueller
patent: 4170593 (1979-10-01), Mueller
patent: 4290953 (1981-09-01), Koizumi
patent: 4559336 (1985-12-01), Mueller
patent: 4559337 (1985-12-01), Mueller
patent: 4614617 (1986-09-01), Mueller
patent: 4704386 (1987-11-01), Mueller
patent: 5182272 (1993-01-01), Hallinan et al.
patent: 5212169 (1993-05-01), Husa et al.
Drug Evaluations, 6th ed (1986), Amer. Medical Assn., pp. 890-892.
The Merck Manual, 15th ed (1987), Merck and Co. Inc., pp. 1296-1297 and 2513.
A. Rakovska, et al., "Antagonistic Effect of SC-19220 on the Responses of Guinea-Pig Gastric Muscles to Prostaglandins E.sub.1, E.sub.2 and F.sub.2," Arch. Int. Pharmacodyn., 268, 59-69 (1984)-USA.
W. E. Coyne, et al., "Anticonvulsant Semicarbazides," J. Med. Chem., 11(6), 1158-1160 (1968)-USA.
K. Gyires, et al., "The Use of the Writhing Test in Mice for Screening Different Types of Analgesics," Arch. Int. Pharmacodyn., 267, 131-140 (1984) USA.
D. E. MacIntyre, et al., "Antagonism of Human Platelet Responses to Stimulatory and Inhibitory Prostaglandins," Prog. Lipid. Res. 20 (1-4), 453-9 (1981)-USA.
R. Gimet, et al., "Quantitative Determination of Polymorphic Forms in a Formulation Matrix Using the Near Infra-Red Reflectance Analysis Technique," J. Pharmaceutical & Biomedical Analysis, vol. 5, No. 3, 205-211 (1987)-USA.
J. H. Sanner, et al., "Structure-Activity Relationships of some Dibenzoxazepine Derivatives as Prostaglandin Antagonists," Advances in the Biosciences, 9, 139-148 (1972)-USA.
Drower, et al., "The Antiociceptive Effects of Prostaglandin Antagonists in the Rat" European Journal of Pharmacology, 133, 249-256 (1987)-Europe.
J. H. Sanner, "Dibenzoxazepine Hydrazides as Prostaglandin Antagonists," Intra-Science Chem. Rept., vol. 6, No. 1, 1-9 (1972)-USA.
K. Nagarajan, et al., "Synthesis of 10,11-Dihydrodibenz[b,f][1,4]oxazepine Derivatives as Potential Anticonvulsants & Psychotropic Agents," Indian Journal of Chemistry, vol. 24B, 840-844 (1985)-India.
Lepore et al, Clinical and Experimental Rheumatology, 9 (Suppl. 6), pp. 33-35 (1991).
Waters et al, Acta Orthop Scand, 62(3), pp. 238-243 (1991).
Searle, PCT Application US92/08103 (unpublished) (1992).
T. Hagen, et al. United States Patent Application, 07/813,316, filed Dec. 20, 1991.
R. Husa, et al. United States Patent Application 07/869,563, filed Apr. 15, 1992.
E. Hallinan, et al. United States Patent Application 07/939,261, filed Sep. 2, 1992.
S. Nakajyo, et al., "Inhibitory Effect of Bassianolide, A Cyclodepsipeptide, on Drug-Induced Contractions of Isolates Smooth Muscle Preparations," Japan. J. Pharmacol., 32, 55-64 (1982)-Japan.
A. Gomes, et al., "Pharmacodynamics of Venom of the Centipede Scolopendra subspinipes dehaani," Indian Journal of Experimental Biology, vol. 20, 615-618 (1982)-India.
A. Bennett, et al., "Antagonism of Prostanoid-Induced Contractions of Rat Gastric Fundus Muscle by SC-19220, Sodium Meclofenamate, Indomethacin or Trimethoquinol," Br. J. Pharmac., 71, 169-175 (1980)-London.
C. A. Maggi, et al., "The Effect of SC-19220, a Prostaglandin Antagonist, on the Micturition Reflex in Rates," European Journal of Pharmacology, 152, 273-279 (1988)-Europe.
George, et al., "Antagonism of Alcohol Hypnosis by Blockade of Prostaglandin Synthesis and Activity: Genotype and Time Course Effects," Pharmacology Biochemistry & Behavior, vol. 19, 131-136 (1983)-USA.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

2-H and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxaze does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-H and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxaze, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-H and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxaze will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-727767

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.