Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1985-02-11
1986-05-20
Reamer, James H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
C07C 49227
Patent
active
045902992
ABSTRACT:
A series of 2-guanidino-4-heteroarylthiazoles, wherein the heteroaryl substituent is selected from thiazolyl, triazolyl, imidazolyl, and 2-alkyl, 2-amino and 2-carboxamido derivatives thereof, are disclosed. The novel compounds have activity as antisecretory agents and histamine H.sub.2 antagonists and are useful for the treatment of gastric hyperacidity and peptic ulcers. Also disclosed are pharmaceutical compositions containing the novel compounds of this invention and a method of using the compounds in the treatment of gastric hyperacidity and peptic ulcers. Novel intermediates useful in the preparation of the novel antisecretory compounds are also described.
REFERENCES:
patent: 2223932 (1940-12-01), Towne
patent: 3259641 (1966-07-01), Castro
patent: 3519637 (1970-07-01), Hoffer
patent: 3646218 (1972-02-01), Last et al.
patent: 3950353 (1976-04-01), Durant et al.
patent: 3970691 (1976-07-01), Sears et al.
patent: 4220654 (1980-09-01), Bolhofer et al.
patent: 4262126 (1981-04-01), Gilman et al.
patent: 4342765 (1982-08-01), Jones et al.
Bokadia, Agra. Univ. J. Research 2, pt. 1, pp. 9-16 (1953).
Bokadia et al., J. Indian Chem. Soc., vol. 30, pp. 383-386 (1953).
Kato et al., Yakugaku Zasshi, vol. 94(7), pp. 884-887 (1974).
Spengler et al., Arzneim-Forsch. 33, 377 (1982).
LaMattina John L.
Lipinski Christopher A.
Blackwood Robert K.
Frost Albert E.
Knuth Charles J.
Pfizer Inc.
Reamer James H.
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