2-Guanidino-4-heteroarylthiazoles

Details 2-Guanidino-4-heteroarylthiazoles 2-Guanidino-4-heteroarylthiazoles

1984-03-27

1985-04-09

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27748

Patent

active

045103135

ABSTRACT:
A series of 2-guanidino-4-heteroarylthiazoles, wherein the heteroaryl substituent is selected from thiazolyl, triazolyl, imidazolyl, and 2-alkyl, 2-amino and 2-carboxamido derivatives thereof, are disclosed. The novel compounds have activity as antisecretory agents and histamine H.sub.2 antagonists and are useful for the treatment of gastric hyperacidity and peptic ulcers. Also disclosed are pharmaceutical compositions containing the novel compounds of this invention and a method of using the compounds in the treatment of gastric hyperacidity and peptic ulcers. Novel intermediates useful in the preparation of the novel antisecretory compounds are also described.

REFERENCES:
patent: 3519637 (1970-07-01), Hoffer
patent: 3950353 (1976-04-01), Durant et al.
patent: 4220654 (1980-09-01), Belhofer et al.
patent: 4262126 (1981-04-01), Gilman et al.
patent: 4342765 (1982-08-01), Jones et al.
Spengler et al., Arzneim.--Forsch. 33, 377 (1983).

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