2-guanidino-4-arylthiazoles for treatment of peptic ulcers

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514370, 546209, 548181, C07D41704, A61K 31425

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active

050267159

ABSTRACT:
2-Guanidino-4-arylthiazole compounds of the formula ##STR1## a pharmaceutically acceptable cationic or acid addition salt thereof wherein

REFERENCES:
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patent: 4374843 (1983-02-01), LaMattina et al.
patent: 4435396 (1984-03-01), LaMattina et al.
patent: 4560690 (1985-12-01), Reiter
patent: 4791200 (1988-12-01), Press
Medicinal Chemistry, Third Edition, Alfred Burger, Ed., Wiley-Interscience, pp. 75-77.
Rachlin, S. et al., "Basic Antiinflammatory Compounds, N,N',N"-Trisubstituted Guanidines", J. Med. Chem. 23, 13-20 (1980).
Lombardino, J. et al., "Potent Antiinflammatory N-Heterocyclic 3-Carboxamides of 4-Hydroxy-2-Methyl-2H-1,2-Benzothiazine 1,1-Dioxide", J. Med. Chem. 16, 493-496 (1973).

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