2-(furanyl alkylamino or thienyl alkylamino or phenylalkylamino)

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514340, 514230, 514228, 514237, 514318, 514349, 514352, 546284, 546283, 546193, 546281, 546297, 546316, 544131, 544124, C07D40912, A61K 3144

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046525726

ABSTRACT:
This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal heterocyclic group. The compounds have histamine H.sub.2 -antagonist activity. A specific compound of this invention is 2-[2-(2-guanidino-4-thiazolylmethylthio)ethyl]amino pyridine 3-carboxylic acid.

REFERENCES:
patent: 3932644 (1976-01-01), Durant et al.
patent: 3954782 (1976-05-01), Fleckenstein et al.
patent: 4218452 (1980-08-01), Brown et al.
patent: 4234588 (1980-11-01), Brown et al.
patent: 4238493 (1980-12-01), Roantree et al.
patent: 4307104 (1981-12-01), Roantree et al.
patent: 4469696 (1984-09-01), Rosentreter et al.
Derwent Abstract 38240C (WP 8000966) May 15, 1980.
Derwent Abstract 64650C (EP 15138) Sep. 3, 1980.

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