2-Formamido phenylguanidines and processes for their preparation

Details 2-Formamido phenylguanidines and processes for their preparation 2-Formamido phenylguanidines and processes for their preparation

1977-02-22

1978-11-28

Thomas, Jr., James O.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560 9, 560 13, 560 25, 560 27, C07C149437, A61K 3127

Patent

active

041276701

ABSTRACT:
N-(2-formamidophenyl)-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(formamido)-phenyl group are anthelminetic agents. The compounds, of which N-(2-formamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoformanilide.

REFERENCES:
patent: 3812173 (1974-05-01), Giraudon
patent: 3828094 (1974-08-01), Widdig
patent: 3835164 (1974-09-01), Widdig
patent: 3869503 (1975-03-01), Widdig
patent: 3993682 (1976-11-01), Kolling

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