2'-fluorofuranosyl derivatives and novel method of preparing 2'-

Details 2'-fluorofuranosyl derivatives and novel method of preparing 2'- 2'-fluorofuranosyl derivatives and novel method of preparing 2'-

1992-10-29

1994-08-09

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07G 300

Patent

active

053367642

ABSTRACT:
A compound has the formula ##STR1## wherein R is selected from the group consisting of (C.sub.7 -C.sub.20)aroyl, (C.sub.6 -C.sub.20)aryl, aralkyl and alkylaryl, and (C.sub.1 -C.sub.10)alkyl-di(C.sub.6 -C.sub.20)aryl Si, R' is selected from the group consisting of (C.sub.1 -C.sub.10)alkyl, (C.sub.7 -C.sub.20)aroyl and (C.sub.2 -C.sub.12)acyl, all of which may be further substituted with O, S, N or alkyl, and R'" is selected from the group consisting of halogen, (C.sub.1 -C.sub.10)alkoxy, (C.sub.1 -C.sub.10)acyloxy, O-methane-sulfonyl and O-p-toluenesulfonyl. A composition of matter comprises 0.001 to 99.999 wt % of the above compound.

REFERENCES:
patent: 4625020 (1986-11-01), Brundidge et al.
patent: 4908440 (1990-03-01), Sterzycki et al.
J. Org. Chem., 50:3644-3647 (1985), Tann et al.
J. Med. Chem. 33:978-985 (1990), Marquez et al.

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