Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-05-09
1996-01-23
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142305, 544101, 544105, A61K 31535, C07D26536, C07D26538
Patent
active
054865158
ABSTRACT:
Compounds of formula I ##STR1## wherein X.sup.a, X.sup.b, R, R.sup.1 and R.sup.2 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful as potassium channel openers for the treatment of urinary incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
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Hiroshi Koga et al. "Synthesis and Antihypertensive Activity of KC-399, A Benzopyran K+ Channel Opener with Long Duration of Action and Less Tachycardia", Bioorganic & Medicinal Chemistry Letters, (1993), 3, No. 10, 2005-2010.
Derek R. Buckle et al. "Relaxant Activity of 4-Amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-Amido-2H-1-benzopyrans on Guinea Pig Isolated Trachealis", J. Med. Chem., (1990), 33, 3028-3034.
Brown Frederick J.
Russell Keith
Warwick, Jr. Paul J.
Grumbling Matthew V.
Hohenschutz Liza D.
Newtson Ruth H.
Zeneca Limited
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