2-fluoro-9-trimethylsilyladenine

Details 2-fluoro-9-trimethylsilyladenine 2-fluoro-9-trimethylsilyladenine

1993-05-20

1999-06-29

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

544267, C07D47300, C07D47340

Patent

active

059170409

ABSTRACT:
A process for the preparation of 2-fluoro-9- (2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine (I) is described. The process involves reacting a protected 2-fluoro adenine with a protected chlorosugar under controlled conditions of temperature (80-85.degree. C.) to produce (I), rather than using a process involving fluorinating a 2-substituted nucleoside precursor of (I).

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