2-Fluoro-1-methylpyridinium salt activated diols and polyols as

Details 2-Fluoro-1-methylpyridinium salt activated diols and polyols as 2-Fluoro-1-methylpyridinium salt activated diols and polyols as

1992-04-16

1993-03-23

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564152, 564153, 564159, 568 38, 568 44, 568 57, C07D21364

Patent

active

051965364

ABSTRACT:
A novel class of cross-linking agent, which comprises a monomeric organic compound having at least two hydroxyl groups each bonded to a different carbon atom, wherein said hydroxyl groups are activated by reaction with 2-fluoro-1-methylpyridinium toluene-4-sulfonate (FMP). Suitable monomeric organic compounds include diols and polyols. Such cross-linking agents may be conveniently prepared by reaction of the monomeric organic compound with FMP in a suitable solvent, followed by recovery of the resultant reaction products, e.g., via precipitation and filtration. The novel cross-linking agents have a wide variety of uses, including the interconnection of subunits of multimeric enzymes and the covalent immobilization of organic ligands to suitable carriers or supports.

REFERENCES:
Ngo, T. T., Biotechnology 4:134 (1986).

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