2-'-ethenylidene cytidine, uridine and guanosine derivatives

Details 2-'-ethenylidene cytidine, uridine and guanosine derivatives 2-'-ethenylidene cytidine, uridine and guanosine derivatives

1994-12-22

1997-04-01

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2714, 536 278, 536 2781, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, 536 2855, 536 41, 544242, 544269, 544272, 544276, 544277, C07H 1973, C07H 19173

Patent

active

056167024

ABSTRACT:
This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.

REFERENCES:
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Katritzky et al., Comprehensive Heterocyclic Chemistry, v vol. 5, Pergamon Press, New York, 1984, see p. 603.
nuki et al., "Design, Synthesis, and Antineoplastic Activity of 2'-Deoxy-2'-methylidenecytidine," J. Med. Chem., 31(6), 1063-1064 (1988).
Fukukawa et al., "Synthesis of 2'(R)-Substituted Neplanocin A's (Nucleosides and Nucleotides XXXVII)," Chem. Pharm. Bull., 29, 597-600 (1981).
Hansske et al., "Nucleic Acid Related Compounds. 43. A Convenient Procedure for the Synthesis of 2'and 3'-Ketonucleosides," Tett. Lett., 34(15), 1589-1592 (1983).
Hansske et al., "2'and 3'-Ketonucleosides and their Arabino and Xylo Reduction Products," Tetrahedron, 40(1), 125-135 (1984).
Taber's Cyclopedic Medical Dictionary, 17th Ed., C. L. Thomas (ed.), F. .A. Davis Co., Philadelphia, PA, 1993, p. 340 only.

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