Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1976-09-28
1979-04-03
Coughlan, Jr., Paul M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
424200, C07F 965, A61K 3141
Patent
active
041478673
ABSTRACT:
2-Dimethylamino-6-diethylenimidophosphamido-7-methylpurine having the formula ##STR1## A method for preparing 2-dimethylamino-6-diethylenimido-phosphamido-7-methylpurine consisting of treating theobromine with heating to the boiling point and subsequently with phosphorus oxychloride and phosphorus pentachloride. The prepared 2,6-dichloro-7-methylpurine is heated to 50.degree.-60.degree. C. in an aqueous solution of ammonia and the resulting 2-chloro-6-amino-7-methylpurine is reacted, with heating, with an aqueous solution of dimethylamine. The obtained 2-dimethylamino-6-amino-7-methylpurine is reacted, at the boiling point, with either phosphorus oxychloride, or phosphorus pentachloride and formic acid. The resulting 2-dimethylamino-7-methylpurinyl-6-aminophosphoric dichloroanhydride is then treated with ethylenemine in a medium of an organic solvent in the presence of an acceptor of hydrogen chloride, and the final product is then isolated.
A preparation for treating malignant tumours of the haemopoietic system containing 2-dimethylamino-6-diethyleneimidophosphamido-7-methylpurine as the active principle is provided.
REFERENCES:
patent: 2663705 (1953-12-01), Parker et al.
patent: 3114751 (1963-12-01), Whetstone
patent: 3666748 (1972-05-01), Honjo et al.
Elderfield, vol. 8, "Heterocyclic Compounds", pp. 288 and 302 (1967).
Chaman Elena S.
Chernov Vladimir A.
Golovchinskaya Elena S.
Korsunsky Vyacheslav S.
Nikolaeva Ljudmila A.
Coughlan, Jr. Paul M.
Springer D. B.
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