[(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates

Details [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates

1992-03-26

1993-12-28

Mars, Howard T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142335, 514305, 544127, 546133, 546137, A61K 3146, C07D45302

Patent

active

052739724

ABSTRACT:
This invention provides novel 2-substituted-3-quinuclidinyl arylcarboxamides and arylthiocarboxamides and corresponding arylcarboxylates which have utility as therapeutic agents which exhibit gastric prokinetic, antiemetic, anxiolytic and 5-HT (serotonin) antagonist effects in warm blooded animals.
Illustrative of an invention compound is 5-chloro-2-methoxy-4-(methylamino)-N-[2-(1-piperidinylmethyl)-1-azabicyclo [2.2.2]oct-3-yl]benzamide: ##STR1## or a pharmaceutically acceptable salt thereof.

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