Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1996-09-06
1999-08-24
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514 25, 514 36, 514343, 514411, 514461, 514473, 514637, 546255, 5462764, 548156, 548157, 548182, 548233, 548255, 5483054, 5483351, 5483411, 564158, 564159, 564347, 564306, A61K 3116, C07C23300
Patent
active
059425474
ABSTRACT:
This invention provides a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.3 independently are hydrogen, --CHO, --COCH.sub.3, --COR.sup.7, --A--Ar--(Q).sub.z, etc.; wherein D is a C.sub.1-6 linear, C.sub.3-8 branched or cyclic group having from 4 to about 15 atoms, consisting of C, etc.; wherein D is unsubstituted or substituted with one or more groups independently selected from the group consisting of --OH, NH.sub.2, --NHR.sub.7, etc.; wherein each Q is independently --CNH(NHY), --NHCNH(NHY), --SO.sub.2 W, --SOW, etc.; wherein Y is hydrogen, alkyl, alkenyl, --B--NH.sub.2, --B--NHR.sup.8, etc.; wherein W is alkyl, alkenyl, --B--NH.sub.2, etc.; wherein A nd B independently are a bond, or a C.sub.1-6 linear, C.sub.3-8 branched or cyclic linking group having from 1 to about 15 atoms, consisting of C, optionally interrupted by N, S, P and O; wherein A and B independently are unsubstituted or substituted with --OH, NH.sub.2, etc.; wherein R.sup.7 is an alkyl, a branched alkyl, etc.; wherein R.sup.8, R.sup.9, and R.sup.10 are independently represented by hydrogen, alkyl, branched alkyl, etc.; wherein x is 0, 1 or 2; and z is 0, 1, 2, or 4; wherein R.sup.1 ' and R.sup.3 ' are independently selected from the group consisting of hydrogen, alkyl and benzyl, or alternatively, R.sup.1 and R.sup.1 ' or R.sup.3 and R.sup.3 ' with their respective nitrogen atoms independently form a phthalimido, succinimido, etc.; wherein R.sup.4, R.sup.5, and R.sup.6 independently are selected from the group consisting of hydrogen, --CHO, --COCH.sub.3, --COR.sup.7, etc.; therein said saccharides are optionally linked at the one position of said saccharid group; wherein R.sup.4 and R.sup.5, or R.sup.5 and R.sup.6, together comprise a methylidene, ethylidene, isopropylident, cyclohexylidene or benzylidene bridge, or R.sup.3 and R.sup.4, or R.sup.1 and R.sup.6, together independently form an intramolecular carbamate; wherein R.sup.5 is not hydrogen or glycosyl when R.sup.3 and R.sup.4, or R.sup.1 and R.sup.6, together independently form an intramolecular carbamate; with the provisio that at least two of R.sup.1, R.sup.1 ', R.sup.3, R.sup.3 ', R.sup.4, R.sup.5, and R.sup.6 are not hydrogen. Also provided are pharmaceutical compositions comprising the compound and methods of inhibiting binding of human immunodeficiency virus REV protein to RRE.
REFERENCES:
patent: 3828021 (1974-08-01), Beattie et al.
patent: 3872080 (1975-03-01), Daniels
patent: 4218561 (1980-08-01), Paulsen
patent: 4396609 (1983-08-01), Daum et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5496938 (1996-03-01), Gold et al.
patent: 5534408 (1996-07-01), Green et al.
patent: 5565324 (1996-10-01), Still et al.
Canas-Rodriguez et al., Carbohydrate Research, 68:43-53, 1979.
Pandey et al., J. of Chromatography, 170:498-501, 1979.
Zapp et al., Cell, 74:969-978, 1993.
CA109: 231413, 1988.
CA95: 25529, 1981.
CA110: 113298, 1988.
CA96: 14880, 1981.
CA89: 215683, 1978.
CA81: 13755, 1974.
CA70: 58219, 1968.
CA62: 2819, 1964.
Gustafson Gary R.
Powers David G.
Wuonola Mark A.
Gupta Yogendra N.
Scriptgen Pharmaceuticals Inc.
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