2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev bind

Details 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev bind 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev bind

1993-09-24

1996-07-09

Kim, Kay K. A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 514 35, 514 36, 514 37, 514 39, 514 40, 514 41, C12Q 170, C12Q 168

Patent

active

055344089

ABSTRACT:
Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule which binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are the 2-deoxystreptamine (2-DOS) aminoglycosides. Disclosed herein are members of the 2-DOS class that are useful for the inhibition of binding of Rev to an RNA containing an RRE. In an HIV infected cell, a consequence of the inhibition of the ability of Rev to bind to the RRE in HIV encoded transcripts is inhibition of HIV replication.

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