Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1998-05-29
2000-11-14
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 243, 536 245, 536 2534, 536 267, 536 277, 435 6, 435 911, C07H 2100, C07H 2104
Patent
active
061471992
ABSTRACT:
2'-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by photochemical irradiation. A further production process is the conversion of deoxyguanosines or guanosines by means of persilylation, reaction with ammonia and deamination in the 2 position. The compounds are suitable as pharmaceutical agents with antiviral efficacy.
REFERENCES:
patent: 5681702 (1997-10-01), Collins et al.
patent: 5780610 (1998-07-01), Collins et al.
Switzer, et al. "Enzymatic Incorporation of a New Base Pair Into DNA and RNA", J.Am.Chem.Soc. 111:8322-8323 (1989).
Kazimierczuk, et al., Preparative Photochemical Synthesis of Isoguanosine Ribe-and Deoxyribonucleosides and Nucleotides, and Isouanosine 3'-5'-cyclic phosphate, a new cAMP analogueActa Biochem Polonica 20(4):395-402 (1973).
Seela, et al., "Furanoside-Pyranoside Isomerization of Tubericiding and its 2'-Deoxy Derivatives--Influence of Nucleobase and Sugar Structure on the Proton Catalyzed Reactoin", J.Chem.Soc. Perkin Trans II 525-530 (1986).
Golas et al., "Preparation and Properties of an Analogue of Poly-(A) and Poly(G): Poly(isoguanylic acid)", Eur.J.Biochem 65: 183-192 (1976).
Cardinaud, "Thin-layer chromatography of purine bases and deoxyribonucleoside analogues IV", J.Chromatog. 154: 345-348 (1978).
Mantsch, et al., "Structural and Enzymatic properties of Adenine T-Oxide Nucleotides", Biochemistry 14(26): 5593-5601 (1975).
Kasimierczuk Zigmunt
Muhlegger Klaus
Seela Frank
von der Eltz Herbert
Boehringer Mannheim
Crane L.
Geist Gary
Lee Victor K.
Petry Douglas A.
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