2'-deoxy-5-substituted uridine derivatives

Details 2'-deoxy-5-substituted uridine derivatives 2'-deoxy-5-substituted uridine derivatives

1989-10-17

1993-10-05

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 281, 536 284, 536 2852, C07H 19073

Patent

active

052506738

ABSTRACT:
Novel 2'-deoxy-5-substituted uridine derivative represented by the general formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a benzoyl group or a tetrahydrofuranyl group; R.sub.2 is a fluorine atom or a trifluoromethyl group; and any one of R.sub.3 and R.sub.4 is a hydrogen atom and the other one is an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group having as the substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents.
The novel 2'-deoxy-5-substituteduridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.

REFERENCES:
patent: 3775397 (1973-11-01), Etzold et al.
patent: 4472386 (1984-09-01), Kodama et al.
patent: 4711955 (1987-12-01), Ward et al.
patent: 4886877 (1989-12-01), Fujii et al.
patent: 5032680 (1991-07-01), Kawai et al.
patent: 5049551 (1991-09-01), Koda et al.
DeClercq, Meth. and Find. Exptl. Clin. Pharmacol., vol. 2(5), pp. 253-267 (1980).
CAbstracts:vol. 101:55487y Japanese Patent 29,699.

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