2'-deoxy-5-fluorouridine derivatives

Details 2'-deoxy-5-fluorouridine derivatives 2'-deoxy-5-fluorouridine derivatives

1988-07-29

1990-08-07

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 19073, A61K 3170

Patent

active

049469517

ABSTRACT:
Disclosed is a 2'-deoxy-5-fluorouridine derivative of the formula ##STR1## wherein one of R.sub.1 and R.sub.2 is a benzyl group which may optionally have substituent selected from the group consisting of C.sub.1 -C.sub.6 alkyl group, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.3 halogenated alkyl group, halogen atom, hydroxyl group and nitro group on the phenyl ring, and the other constitutes an amino acid residue, or a salt thereof. The compounds are useful for treating cancer.

REFERENCES:
patent: 4340728 (1982-07-01), Endo et al.
patent: 4599404 (1988-07-01), Fujii et al.
patent: 4605645 (1986-08-01), Watanabe et al.
patent: 4757139 (1988-07-01), Kawaguchi et al.

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