2'-deoxy-5-fluorouridine derivatives

Details 2'-deoxy-5-fluorouridine derivatives 2'-deoxy-5-fluorouridine derivatives

1989-02-24

1991-07-16

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 29, 544243, 544311, 544313, A01N 4304, A61K 3170, C07H 1702

Patent

active

050326805

ABSTRACT:
2'-Deoxy-5-fluorouridine derivatives of the formula ##STR1## wherein, R.sup.1 is hydrogen atom or an acyl group and R.sup.2 and R.sup.3 are respectively hydrogen atom, an acyl group or a group of the formula ##STR2## wherein X.sup.1 and X.sup.2 are respectively oxygen atom or sulfur atom; R.sup.4 is a phenyl group, a benzyl group or a naphthyl group each of which may be substituted by an alkyl group, an alkoxyl group, an alkoxycarbonyl group, an alkylthio group, and acyl group, a halogen atom, trifluoromethyl group, nitro group, cyano group, carboxyl group and/or methylenedioxy group and R.sup.5 is an alkyl group, an alkenyl group or one of the groups represented by R.sup.4 which is the same as or different from R.sup.4, at least one of R.sup.2 and R.sup.3 being a group of the formula ##STR3## which exhibit excellent antitumour activities and have lower toxicity, methods of the production thereof and antitumour compositions containing said 2'-deoxy-5-fluorouridine derivatives.

REFERENCES:
patent: 4503045 (1985-03-01), Fujii
patent: 4599404 (1986-07-01), Fujii
patent: 4605645 (1986-08-01), Watanabe
patent: 4684631 (1987-08-01), Hori
patent: 4740503 (1988-04-01), Hori

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