Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1981-12-21
1984-01-03
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 23, 544309, A61K 3170, C07H 1908
Patent
active
044242115
ABSTRACT:
The novel substance E-5-(2-bromovinyl)-2'-deoxyuridine and its corresponding iodovinyl derivative are gifted with specific antiviral activities towards herpes simplex virus. They may be synthesized by a condensation reaction followed by separation of anomers.
REFERENCES:
patent: 3748320 (1973-07-01), Vorbruggen et al.
patent: 3817980 (1974-06-01), Vorbruggen et al.
patent: 3891623 (1975-06-01), Vorbruggen et al.
patent: 4093715 (1978-06-01), Lin et al.
patent: 4093716 (1978-06-01), Lin et al.
patent: 4182859 (1980-01-01), Erhardt
Perman et al., Tetrahedron Letters 28 (1976) pp. 2427-2430.
Domin et al., Pharmacologist 17, 229 (1974).
Bobek et al., Chemistry and Biology of Nucleosides and Nucleotides (Ed Harmon, Robbins and Townsend 1978) pp. 135-148.
Baerwolff et al., Nucleic Acid Research, Spec. Publ. No. 1, (1975) pp. 529-531.
Jones et al., Tetrahedron Letters, No. 28, Jul. 1977, pp. 2459-2460.
Prusoff and Goz: Handbook of Experimental Pharmacology, Part II of Antineoplastic and Immunosuppressive Agent, (Ed Sartorelli and Johns), New York 1975.
Cheng et al., Antimicrobial Agents and Chemotherapy, 10,1, pp. 119-122.
C. C. Bhat, Synthetic Procedures in Nucleic Acid Chemistry (Ed Tipson and Zorbach), vol. 1, pp. 521-522 (1968).
Bleackley et al., Tetrahedron Letters, 32, pp. 2795-2797 (1976).
Bobek et al., J. Org. Chemistry, 40, pp. 2377-2379 (1975).
De Clercq et al., Biochemical Pharmacology, 24, pp. 532, 527 (1975).
De Clercq et al., Biochemical Pharmacology, 26, pp. 794-797 (1977).
Barr Philip J.
De Clercq Erik D. A.
Jones Albert S.
Walker Richard T.
Brown Johnnie R.
Rega Instituut VZW
University of Birmingham
LandOfFree
2'Deoxy-5-(2-halogenovinyl)-uridines, pharmaceutical composition does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2'Deoxy-5-(2-halogenovinyl)-uridines, pharmaceutical composition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2'Deoxy-5-(2-halogenovinyl)-uridines, pharmaceutical composition will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1031686