2'deoxy-2'-alkylnucleotide containing nucleic acid

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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435 6, 435 5, 536 245, 514 44, C12P 1934, C12Q 168, C12Q 170, C07H 2104

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056270534

ABSTRACT:
2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5180818 (1993-01-01), Cech et al.
patent: 5334711 (1994-08-01), Sproat et al.
Fraser et al. J. Heterocyclic Chemistry 30:1277-1287. 1993.
Matsuda et al. J. Med. Chem. 34:234-239. 1991.
Awano et al., "Nucleosides and Nucleotides. 128. (2'S)-2'-Deoxy-2'-C-methyl-5-lodourine (SMIU) as a Novel Potent Anti-Herpes Virus Agent," Biooganic & Medicinal Chemistry Letters4:367-370 (1994).
Cicero et al., "Steroselective Synthesis of Novel Analogues of 2'-Deoxy-and 2', 3'Dideoxynucleosides with Potential Antiviral Activity," Biooganic & Medicinal Chemistry Letters4:861-866 (1994).
Garg et al., "New Synthesis of 3'-C-substituted-3
itromethyl-ribo-thymidines," Tetrahedron50:4167-4178 (1994).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P is the Catalytic Subunit of the Enzyme," Cell35:849-857 (1983).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA," Nucleic Acids Research18:299-304 (1990).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)s TRSV Sequence," Biochemistry28:4929-4933 (1989).
Hassan et al., "Nucleosides and Nucleotides. 110. [2,3]-Sigmatropic Rearrangement of the Ally,lic Selenides to Allylic Amines in Sugar Moeity of Pyrimidine Nucleosides: Synthesis of 3'-Amino-2', 3'-dideoxy-2'-methylidenecytidine," Heterocycles34:657-661 (1992).
Ballantyne et al., "Nucleotide sequence of the cDNA for murine intercellular adhesion molecule-1 (ICAM-1)," Nucleic Acids Research17:5853 (1989).
Barinaga, "Ribozymes: Killing the Messenger," Science262:1512-1514 (1993).
Cotten, "The in vivo application of ribozymes," TIBTECH8:174-178 (1990).
Edington, "Ribozymes: Stop Making Sense," Biotechnology10:256-262 (1992).
Kita et al., "Sequence and expression of rat ICAM-1," Biochem. Biophys. Acta1131:108-110 (1992).
Simons et al., "ICAM, an adhesion ligand of LFA-1, is homologous to the neutral cell adhesion molecule NCAM,", Nature331:624-627 (1988).
Ioannidis et al., "Synthesis of 2', 3'-Didehydro-2', 3'-2'-C'methyl substituted Nucleosides Using a Novel Sn2' Type Reaction," Nucleosides Nucleotides12:449-462 (1993).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research17:1371-1377 (1989).
Lin et al., "Synthesis and Anticancer and Antiviral Activities of Various 2'-and 3'-Methylidene-Substituted Nucleoside Analogues and Crystal Structure of 2'-Deoxy -2'-methylidenecytidine Hydrochloride," J. Med. Chem.34:2607-2615 (1991).
Matsuda et al., "Radical Deoxygenation of tert-Alcohols in 2'-Branched-chain Sugar Pyrimidine Nucleosides: Synthesis and Antileukemic Activity of 2'-Deoxy -2'(s)-methylcytidine," Chem. Pharm. Bull.35:3967-3970 (1987).
Matsuda et al., "Nucleosides and Nucleotides. 94. Radical Deoxygenation of ter-Alcohols in 1-(2-C-Alkylpentofuranosyl) pyrimidines: Synthesis of (2'S)-2'-C-methylcytidine," J. Med. Chem.34:234-239 (1991).
Perreault et al., "Mixed Deoxyribo-and Ribo-Oligonucleotides with Catalytic Activity," Nature344:565-567 (1990).
Perrotta and Been,"Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemistry31:16-21 (1992).
Pieken et al., "Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes," Science253:314-317 (1991).
Rossi et al, "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Aids Research and Human Retroviruses8:183-189 (1992).
Samano et al., "Nucleic Acid Related Compounds. 77. 2',3'-Didehydro-2', 3'-dideoxy-2'(and 3')-methylnucleosides via [3,2]-Sigmatropic Rearrangements of 2'(and 3') Methylene-3'(and 2')-O-thiocarbonyl Derivaties and Radical Reduction of a 2'-Chlor-3'-methylene Analogue," Can. J. Chem., 71:186-191 (1993).
Samano et al., "Nucleic Acid Related Compounds., 70. Synthesis of 2'(and 3')-Deoxy-2'(and 3')-methyleneadenosines and Bis(methylene)furan 4', 5'-Didehydro-5'deoxy-2'(and 3')-methyleneadenosines. Inhibitors of S-Adenosyl-L-homocysteine Hydrolase and Ribonucleotides Reductase" J. Org. Chem.56:7108-7113 (1991).
Usman and Cedergren, "Exploiting the chemical synthesis of RNA," TIBS17:334-339 (1992).

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