Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1996-09-12
1999-11-16
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435199, 536 241, 536 245, 536 251, C12P 1934, C12N 922, C07H 2100
Patent
active
059856211
ABSTRACT:
2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5180818 (1993-01-01), Cech et al.
patent: 5639647 (1997-06-01), Usman et al.
Ballantyne et al., "Nucleotide sequence of the cDNA for murine intercellular adhesion molecule-1 (ICAM-1)," Nucleic Acids Research 17:5853 (1989).
Barinaga, "Ribozymes: Killing the Messenger," Science 262:1512-1514 (1993).
Bjergarde et al., "Solid Phase Synthesis of Oligodeoxyribonucleoside phosphorodithioates from thiophosphoramidites," Nucleic Acids Research 21:58453-5850 (1991).
Brink et al., "2-C-Nitromethyl and 2-C-Aminomethyl Derivatives of D-Ribose. Preparation of 2'-C-Nitromethyluridines," J.C.S. Perkin I 1608-1612 (1977).
Cotten, "The in vivo application of ribozymes," TIBTECH 8:174-178 (1990).
Edgington, "Ribozymes: Stop Making Sense," Biotechnology 10:256-262 (1992).
Guerrier-Takada, et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35:849-857 (1983).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)s TRSV Sequence," Biochemistry 28:4929-4933 (1989).
Hampel et al., "Hairpin Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA," Nucleic Acids Research 18:299-304 (1990).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989).
Kita et al., "Sequence and expression of rat ICAM-1," Biochem. Biophys. Acta 1131:108-110 (1992).
Perreault et al., "Mixed Deoxyribo-and Ribo-Oligonucleotides with Catalytic Activity," Nature 344:565-567 (1990).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemistry 31:16-21 (1992).
Pieken et al., "Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes," Science 253:314-317 (1991).
Rossi et al., "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Aids Research and Human Retroviruses 8:183-189 (1992).
Simmons et al., "ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM," Nature 331:624-627 (1988).
Sproat et al., "New Synthetic routes to synthons suitable for 2'-O-allyloligoribonucleotide assembly," Nucleic Acids Research 19:733-738 (1991).
Sproat et al., "2'-O-Alkyloligoribonucleotides: Synthesis and Applications in Studying RNA Splicing," Nucleosides &Nucleotides 10:25-36 (1991).
Sproat et al., "New synthetic routes to protected purine 2'-O'methylriboside-3'-O-phosphoramidites using a novel alkylation procedure," Nucleic Acids Research 18:41-49 (1990).
Stein et al., "Physiocochemical properties of phosphorothioate oligodeoxynucleotides," Nucleic Acids Research 16:3209-3221 (1988).
Tseng et al., "A Ring-Enlarged Oxetanocin A Analogue as an Inhibitor of HIV Infectivity," J. Med. Chem. 34:343-349 (1991).
Uhlenbeck, "A Small Catalytic Oligoribonucleotide," Nature 328:596-600 (1987).
Usman and Cedergren, "Exploiting the chemical synthesis of RNA," TIBS 17:334-339 (1992).
Xi et al., "New Stereocontrolled Synthesis of Isomeric C-Branched-.beta.-D-Nucleosides by Intramolecular Free-radical Cyclization-Opening Reactions Based on Temporary Silicon Connection," Tetrahedron 48:349-370 (1992).
Beigelman Leonid
Karpeisky Alexander
Modak Anil
Usman Nassim
Guzo David
Ribozyme Pharmaceuticals Inc.
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