2'-deoxy-2',2'-difluoro (4-substituted pyrimidine) nucleosides,

Details 2'-deoxy-2',2'-difluoro (4-substituted pyrimidine) nucleosides, 2'-deoxy-2',2'-difluoro (4-substituted pyrimidine) nucleosides,

1993-10-29

1995-07-04

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 514 49, 514 50, 536 2713, 536 284, 536 285, 536 2853, A61K 3170, C07H 19067, C07H 1923

Patent

active

054300266

ABSTRACT:
The invention provides certain 2-Deoxy-2,2-Difluoro (4-Substituted) Pyrimidine Nucleosides that are effective as anti-cancer agents and in treating viral infections.

REFERENCES:
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patent: 4965374 (1990-10-01), Chou et al.
patent: 5061793 (1991-10-01), Grindey et al.
Miller et al., "Alkaloids of Vinca rosea L. (Cantharanthus roseus G. Don). 38. 4'-Dehydrated Derivatives," J. Med. Chem., 20(3), 409-413 (1977).
Sweeney et al., "Antitumor Activity of Deacetyl Vinblastine Amide Sulfate (Vindesine) in Rodents and Mitotic Accumulation Studies in Culture," Cancer Research, 38, 2886-2891 (1978).
Watanabe, K. A., et al., Synthesis and Anti-HIV-1 Activity of 2'-"up"-Fluoro Analogues of Active Anti-AIDS Nucleosides 3'Azido-deoxythymidine (AZT) and 2',3'-Dideoxycytidine (DDC), J. Med. Chem. 33, 2145-2150 (1990).
Sterzycki, R. Z., et al., Synthesis and Anti-HIV-1 Activity of Several 2'-Fluoro Containing Pyrimidine Nucleosides, J. Med. Chem. 33, 2150-2157 (1990).
R. S. Root-Bernstein, "AiIDS is more than HIV: Part II", Genetic Engineering News, Sep. 15, 1992, pp. 4-5.
R. S. Root-Bernstein, "AIDS is more than HIV: Part I", Genetic Engineering News, Sep. 1, 1992, pp. 4-6.

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