2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives

Details 2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives 2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives

1990-11-09

1993-12-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

514573, 514530, A61K 31557, A61K 31765

Patent

active

052700496

ABSTRACT:
The present invention concerns 2-decarboxyl-2-aminoalkyl derivatives of naturally occurring and synthetic prostaglandins, N-substituted derivatives, ester prodrugs and homologues of such compounds that are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.

REFERENCES:
patent: 4085139 (1978-04-01), Nelson
patent: 4599353 (1986-07-01), Bito
patent: 4883819 (1989-11-01), Bito
patent: 4927846 (1990-05-01), Gluchowski
patent: 4952581 (1990-08-01), Bito et al.
patent: 4994274 (1991-02-01), Chan et al.
patent: 5001153 (1991-03-01), Ueno et al.
patent: 5011856 (1991-04-01), Woodward
Nelson et al. "2-(aminomethyl)-2-decarboxyprostaglandin F2x Type Analogs", Prostaglandins 17(3), 1979, 441-449.

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