2-Decarboxy-2-hydroxymethyl PGF.sub.2 .alpha.analogs

Details 2-Decarboxy-2-hydroxymethyl PGF.sub.2 .alpha.analogs 2-Decarboxy-2-hydroxymethyl PGF.sub.2 .alpha.analogs

1979-03-15

1980-06-24

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C17700

Patent

active

042096456

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
Derwent Abstract, 42368x/23, Imperial Chem. Inds. Ltd., 26.05.76.
Derwent Abstract, 47634a/26, U.S. 4088-691, Upjohn Co., (09.05.78).
Derwent Abstract, 47633a/26, U.S. 4088-690, Upjohn, (09.05.78).
Chem. Abstr., 87.22553f, Fried, Josef, Gen. Offen., 2,640,487.

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