2-Decarboxy-2-hydroxymethyl-PGF.sub.1 .alpha. analogs

Details 2-Decarboxy-2-hydroxymethyl-PGF.sub.1 .alpha. analogs 2-Decarboxy-2-hydroxymethyl-PGF.sub.1 .alpha. analogs

1977-04-06

1979-10-16

Schwartz, Gerald A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C17700

Patent

active

041714601

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3914282 (1975-10-01), Pike
patent: 3932463 (1976-01-01), Schaub et al.
patent: 3933889 (1976-01-01), Magerlein
patent: 3959346 (1976-05-01), Schneider
patent: 3962293 (1976-06-01), Magerlein
Derwent Farmdoc, CPI 22,600 (Jan. 9, 1966).
Burger, "Medicinal Chemistry", pp. 81-82 (1960).

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