2 -Decarboxy-2-hydroxymethyl-3,7-inter-m-phenylene-3-oxa-9-deoxy

Details 2 -Decarboxy-2-hydroxymethyl-3,7-inter-m-phenylene-3-oxa-9-deoxy 2 -Decarboxy-2-hydroxymethyl-3,7-inter-m-phenylene-3-oxa-9-deoxy

1977-03-17

1978-02-28

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 4982

Patent

active

040767507

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3810943 (1974-05-01), Jones et al.
patent: 3933892 (1976-01-01), Chadha et al.
patent: 3962312 (1976-06-01), Hayashi et al.
Pake, J. Org. Chem., vol. 34, p. 3552 (1969).

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