2-Decarboxy-2-hydroxymethyl-17-phenyl-11-deoxy-PGF.sub.1 analogs

Details 2-Decarboxy-2-hydroxymethyl-17-phenyl-11-deoxy-PGF.sub.1 analogs 2-Decarboxy-2-hydroxymethyl-17-phenyl-11-deoxy-PGF.sub.1 analogs

1977-08-05

1978-11-28

Schwartz, Gerald A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568645, 568646, 424341, 424343, C07C17700

Patent

active

041277333

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3914282 (1975-10-01), Pike
patent: 3932463 (1976-01-01), Schaub et al.
patent: 3933889 (1976-01-01), Magerlein
patent: 3959346 (1976-05-01), Schneidner
patent: 3962293 (1976-06-01), Magerlein
Burger, "Medicinal Chemistry" pp. 81-82 (1960).
Derwent Farmdoc CPI No. 07432w/05 (11-07-73).
Derwent Farmdoc CPI No. 13108w/08 (02-08-73).

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