2-Decarboxy-2-hydroxymethyl-16-fluoro-PGE.sub.2 compounds

Details 2-Decarboxy-2-hydroxymethyl-16-fluoro-PGE.sub.2 compounds 2-Decarboxy-2-hydroxymethyl-16-fluoro-PGE.sub.2 compounds

1978-10-13

1980-10-21

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C17700

Patent

active

042293774

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 4032576 (1977-06-01), Nelson

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