2-Decarboxy-2-hydroxy-methyl-13,14-didehydro-17-phenyl PGF compo

Details 2-Decarboxy-2-hydroxy-methyl-13,14-didehydro-17-phenyl PGF compo 2-Decarboxy-2-hydroxy-methyl-13,14-didehydro-17-phenyl PGF compo

1978-02-24

1980-06-03

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568646, 568807, C07C 3521

Patent

active

042063116

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol and the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3932496 (1976-01-01), Jung

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