2-Decarboxy-2-hydroxy-methyl-13,14-didehydro-16-phenoxy PGF comp

Details 2-Decarboxy-2-hydroxy-methyl-13,14-didehydro-16-phenoxy PGF comp 2-Decarboxy-2-hydroxy-methyl-13,14-didehydro-16-phenoxy PGF comp

1978-02-24

1978-12-19

Schwartz, Gerald A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568646, C07C17700

Patent

active

041305914

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol and the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3810943 (1974-05-01), Jones et al.
patent: 3932496 (1976-01-01), Jung
patent: 3935254 (1976-01-01), Gandolfe et al.
patent: 3984400 (1976-10-01), Egglev et al.
Fried et al., J. Med. Chem., vol. 16, No. 4, pp. 429-430 (1973).
Fried et al., Annals of the New York Academy of Sciences, 180:38 (1971).

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