2-Decarboxy-2-aminomethyl-6a-carba-PGI.sub.2 compounds

Details 2-Decarboxy-2-aminomethyl-6a-carba-PGI.sub.2 compounds 2-Decarboxy-2-aminomethyl-6a-carba-PGI.sub.2 compounds

1979-09-27

1980-12-09

Doll, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

2603405P, 2603459P, 560 53, 560 56, 560119, 560256, 562462, 562466, 562501, 424269, 424305, 424308, 424317, 424320, 424324, 424325, 424330, 424331, 424339, 424341, 424343, C07C 9102, C07C 9140

Patent

active

042384141

ABSTRACT:
The present invention relates to novel 2-decarboxy-2-aminomethyl-6a-carba-PGI.sub.2 compounds, which are useful for inducing a variety of prostacyclin-like pharmacological effects. Accordingly, these compounds are useful pharmacological agents for the same purposes for which prostacyclin is employed.

REFERENCES:
patent: 3776940 (1973-12-01), Just et al.
patent: 3862979 (1975-01-01), Gandolfi et al.
patent: 3935240 (1976-01-01), Mallion
Bundy et al., "Tetrahedron Letters", No. 16, pp. 1371-1374 (1978).
Kojima et al., "Tetrahedron Letters", No. 39, pp. 3743-3746 (1978).
Nicolaou et al., "J.C.S., Chemical Communications", p. 1067 (1978).

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