(.+-.)-2-Cyclobutylmethyl-9.alpha.,10.beta.-dihydroxy-1.beta.-(p

Details (.+-.)-2-Cyclobutylmethyl-9.alpha.,10.beta.-dihydroxy-1.beta.-(p (.+-.)-2-Cyclobutylmethyl-9.alpha.,10.beta.-dihydroxy-1.beta.-(p

1977-09-28

1979-05-08

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21704

Patent

active

041536037

ABSTRACT:
N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound N-Cyclobutylmethyl-3,14-dihydroxymorphinan has been found to possess potent agonist/antagonist activity as a non-narcotic analgesic. A new and efficient total synthesis of these compounds is described herein from the starting material 2-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline.

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