2-Cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid ester deriva

Details 2-Cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid ester deriva 2-Cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid ester deriva

1982-08-25

1984-05-08

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546187, 546198, 548241, 2602444, C07D41314, A61K 3142

Patent

active

044474393

ABSTRACT:
Novel 2-cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen or a halogen atom, R.sub.2 is a lower alkyl group, Am is a 5- to 9-membered saturated cyclic amino group which may be substituted by a lower alkyl group, and the group: ##STR2## binds to the piperidine moiety at 3- or 4-position of the latter, and their pharmaceutically acceptable acid addition salts and quaternary ammonium salts, process for their preparation, and pharmaceutical compositions containing these compounds. They have potent anticholinergic antispasmodic activity, while they are weak in side effects such as mydriasis, inhibition of salivary secretion and tachycardia.

REFERENCES:
patent: 2626260 (1953-01-01), Clinton et al.
patent: 4355037 (1982-10-01), Strupszewski et al.
patent: 4390544 (1983-06-01), Davis et al.
patent: 4396770 (1983-08-01), Davis et al.
Reetz, Chem. Abstracts, vol. 53:413a (1959).
Chem. Abstracts, vol. 67:2990e (1967).
Vitali et al., Chem. Abstracts, vol. 72:31781w (1970).
Pigini et al., Chem. Abstracts, vol. 83:193144v (1975).

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