2-cyanopiperazine and method of producing the same

Details 2-cyanopiperazine and method of producing the same 2-cyanopiperazine and method of producing the same

1996-07-18

1997-12-16

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544390, C07D 2404

Patent

active

056986971

ABSTRACT:
2-Cyanopiperazine represented by the following formula (1): ##STR1## or a salt thereof. The 2-cyanopiperazine can be produced by reacting a 2-halogenoacrylonitrile with ethylenediamine or by reacting a 2,3-dihalogenopropionitrile with ethylenediamine.
The 2-cyanopiperazine is useful as an intermediate for medicaments, agricultural chemicals, etc., and optically active N-tert-butyl-2-piperazine carboxamide, which is useful as an intermediate in preparation of the HIV protease inhibitor indinavir, can be easily produced using the 2-cyanopiperazine.

REFERENCES:
patent: 4925901 (1990-05-01), Bertram et al.
patent: 5612484 (1997-03-01), Askin et al.
Rossen, et al., "Asymmetric Hydrogenation of Tetrahydropyrazines: Synthesis of (S)--Piperazine-2-tert-butylcarboxamide, an Intermediate in the Preparation of the HIV Protease Inhibitor Indinavir", Tetrahedron Letters, vol. 36, No. 36, pp. 6419-6422, 1995.

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