2'-Cyano pyrimidine nucleoside compounds

Details 2'-Cyano pyrimidine nucleoside compounds 2'-Cyano pyrimidine nucleoside compounds

1994-09-07

1997-04-01

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 50, 514908, 536 274, 536 281, 536 282, 536 284, 536 285, 536 2852, 536 2853, 536 2854, A61K 3170, C07H 1906, C07H 1909

Patent

active

056165676

ABSTRACT:
The pyrimidine compounds of the present invention are represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein, R.sup.1 represents a hydroxyl or an amino which may be substituted by an acyl group; R.sup.2 represents a hydrogen atom or an alkyl having 1 to 4 carbons; R.sup.3 represents a hydrogen or a hydroxyl; and R.sup.4 and R.sup.5 each represent a hydrogen or together form a group --R.sup.6 R.sup.7 Si--O--SiR.sup.6' R.sup.7' --, wherein R.sup.6, R.sup.7, R.sup.6' and R.sup.7' are the same or different from one another and each represent an alkyl having 1 to 4 carbons. The compounds of the present invention exhibit an excellent antitumor effect.

REFERENCES:
Dieter Habich, et al, "Synthesis of 3'-Cyano-3'-deoxy-.beta.-D-arabino-nucleosides", 1988, pp. 943-947, Synthesis.
Dong Yu et al, "Synthesis of 3'-Cyano-2',3'-dideoyadenosine and 2',3'-Dideoxy-3'-formyladenosine", 1989, pp. 3240-3342, J. Org. Chem.
CA 115(3):29817a (1991) Makuda et al.
J. Med. Chem. vol. 34(9) 2917-2919.
Scientific American (Jan. 1994) vol. 270 No. 1, Beardsley.

Affiliated with

Also associated with

Rating

2'-Cyano pyrimidine nucleoside compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2'-Cyano pyrimidine nucleoside compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2'-Cyano pyrimidine nucleoside compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-538956