Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-04-28
1977-03-15
Gotts, Lewis
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2603432R, 2603433R, 260349, 260448AD, 260465E, 260465F, 260465G, 424 87, 424304, 424281, 07C12180, C07C12175, C07C12176
Patent
active
040124070
ABSTRACT:
Pharmaceutical compositions are produced comprising as the active ingredient a compound of the formula ##STR1## or a pharmaceutically acceptable, nontoxic salt thereof or hydrate thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, halogen, lower alkyl or lower alkoxy, or any two of the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4, taken together with the carbon atoms to which they are joined complete a substituted or unsubstituted carbocyclic ring, and X is a bond or an oxygen atom, is combined with a pharmaceutically acceptable, nontoxic inert diluent or carrier. Those compounds wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all simultaneously hydrogen are novel.
When X is a bond, the compounds may be prepared by reacting an appropriately substituted 3-dyanomethylene phthalide with a base and, thereafter, if desired, converting the compound to a salt. When X is an oxygen atom, the compounds may be prepared by reacting a suitably substituted benzene derivative with an activated carbonyl group having a carbanion of the formula NC--CH--R, wherein R is a carboxylic acid ester group, and thereafter, if desired, converting the compound into a salt.
REFERENCES:
zugravescu et al.: Chemical Abstracts, vol. 59, pp. 6399-6499 (1963).
Gudrinietse et al.: J. Org. Chem. - USSR, vol. 9, p. 1337 (1973).
Vanags et al.: Chemical Abstracts, vol. 64, p. 4201 (1966).
Buckle Derek Richard
Cantello Barrie Christian Charles
Doyle Frank Peter
Smith Harry
Beecham Group Limited
Gotts Lewis
Torrence Dolph H.
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