2-cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives

Details 2-cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives 2-cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives

1997-09-10

2000-09-19

Dees, Jose'G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514519, 514520, 558390, 558392, 558393, A61K 31275, C07C25500

Patent

active

061213160

ABSTRACT:
2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or dissorders whose course involves increased connective tissue or cartilage degradation.

REFERENCES:
Hart, "Current Concepts in the Rheumatic Diseases: Etiology and Treatment," Seminars in Arthritis and Rheumatism, 15(2)(1):4-7 (1985).
Kang et al., "Scientific Workshop on the Biology and Pathology of Acquired Connective Tissue Diseases," Arthritis and Rheumatism, 35(11):1289-1295 (1992).
Coughlan et al., (CA 123:285095, abstract of WO 9424095).
Derwent Abstract of EP-A-0 652 214.
Sizov et al., "Acylation of Cyanoacetic Ester With Diacid Chlorides Under Phase Transfer Catalysis," Chemical Abstracts, vol. 109, No. 13, Abstract No. 109846a, 1988.
D. Burkhardt et al., "Laboratory Evaluation of Glycosaminoglycan Polysulphate Ester for Chondroprotective Activity: A Review", Current Therapeutic Research, 40 (6) :1034-1053 (1986).

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