2-component immunoadjuvant

Details 2-component immunoadjuvant 2-component immunoadjuvant

1989-04-17

1992-04-28

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Carbohydrate or lignin, or derivative

514788, 514939, A61K 4700

Patent

active

051090260

ABSTRACT:
An immunoadjuvant capable of producing secondary antibody responses as great as 50 to 60% of those obtained using Freund's complete adjuvant (FCA) which responses decline at a slow rate while not showing the disadvantages associated with FCA. The immunoadjuvant comprises an immunoadjuvant oil such as a mineral oil, squalene or squalane and a polycationic polyelectrolyte immunoadjuvant such as DEAE-Dextran or polyethyleneimine. The immunoadjuvant preferably comprises an emulsion having the oil in one phase and an aqueous solution of the polycationic polyelectrolyte in the other phases. Such immunoadjuvants are used with antigens, such as conjugates of hormones, e.g. luteinizing hormone releasing hormone, and an immunogenic protein.

REFERENCES:
patent: 4258029 (1981-03-01), Moloney et al.
Derwent Abstract Accession No. 85-097598/16, Class D16, SU, A, 1115-754 (MOSC MED PIROGOV), Sep. 30, 1984.
Bach, Jean-Francois (Ed) `Immunology`, published 1978, by John Wiley & Sons Inc. (USA), see pp. 815-816.
Woodward L. F. & Jasman R. L., `Stable Oil-in-Water Emulsions: Preparation and use as Vaccine Vehicles for Lipophilic Adjuvants` Vaccine, vol. 3, Jun. 1985, pp. 137-144.

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