2-chloro and 2-bromo derivatives of 1,5-iminosugars

Details 2-chloro and 2-bromo derivatives of 1,5-iminosugars 2-chloro and 2-bromo derivatives of 1,5-iminosugars

1995-03-06

1997-01-21

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

546 6, 546 14, A61K 31445, C07D21194

Patent

active

055959814

ABSTRACT:
Novel 2-chloro and 2-bromo derivatives of 1,5-iminosugars are disclosed, especially such derivatives of 1,5-dideoxy-1,5-imino-D-glucitol. These compounds are useful inhibitors of glucosidase enzymes and also are useful as antiviral agents and as intermediates for the synthesis of other enzyme inhibitors and antiviral compounds.

REFERENCES:
patent: 4849430 (1989-07-01), Fleet et al.
patent: 5003072 (1991-03-01), Partis et al.
patent: 5025021 (1991-06-01), Getman
patent: 5030638 (1991-07-01), Partis et al.
patent: 5206251 (1993-04-01), Khanna et al.
patent: 5258518 (1993-11-01), Khanna et al.
patent: 5268482 (1993-12-01), Koszyk et al.
patent: 5276120 (1994-01-01), Wong
Greene, T. W. Protective Groups in Organic Synthesis, John Wiley and Sons, Inc. 1981, pp. 39-50.
Furneaux et al; Tetrahedron 50 (7), 2131-2160 (1994).
Baxter & Reitz, J. Org. Chem. 59, 3175-3185 (1994).
Takaoka et al., J. Org. Chem. 58, 4809-4812 (1993).
Fleet & Smith, Tetrahedron 43, 971-978 (1987).
Fleet & Smith, Tetrahedron Lett. 26, 1469-1472 (1985).
Legler, et al., J. Am. Chem. Soc. 113, 6187-6196 (1991).

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