2-chloro and 2-bromo derivatives of 1,5-iminosugars

Details 2-chloro and 2-bromo derivatives of 1,5-iminosugars 2-chloro and 2-bromo derivatives of 1,5-iminosugars

1994-03-08

1995-09-19

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546220, C07D21140

Patent

active

054516790

ABSTRACT:
Novel 2-chloro and 2-bromo derivatives of 1,5-iminosugars are disclosed, especially such derivatives of 1,5-dideoxy-1,5-imino-D-glucitol. These compounds are useful inhibitors of glucosidase enzymes and also are useful as antiviral agents and as intermediates for the synthesis of other enzyme inhibitors and antiviral compounds.

REFERENCES:
patent: 4849430 (1989-07-01), Fleet et al.
patent: 5003072 (1991-03-01), Partis et al.
patent: 5025021 (1991-06-01), Getman et al.
patent: 5030638 (1991-07-01), Partis et al.
patent: 5206251 (1993-04-01), Khanna et al.
patent: 5258518 (1993-11-01), Khanna et al.
patent: 5268482 (1993-12-01), Koszyk et al.
Furneaux et al., Tetrahedron, vol. 50, No. 7, pp. 2131-2160 (1994).
Fleet et al., FEBS Lett. 237, 128-132 (1988).

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